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COMPLEMENT C3 NEPHRITIC FACTOR
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DeCS
Descriptor
English
:
Complement C3 Nephritic Factor
Descriptor
Spanish
:
Factor Nefrítico del Complemento 3
Descriptor
Portuguese
:
Fator Nefrítico do Complemento 3
Tree Number:
D12.776.124.486.274.920.287
D12.776.124.486.485.114.323.300
D12.776.124.790.651.114.323.300
D12.776.377.715.548.114.323.300
Definition
English
:
An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in
serum
of
patients
with MESANGIOCAPILLARY
GLOMERULONEPHRITIS
. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (
COMPLEMENT FACTOR H
;
COMPLEMENT FACTOR I
). This abnormally stabilized enzyme induces a continuous
COMPLEMENT ACTIVATION
and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
Pharmacological Action:
Complement Inactivating Agents
Immunologic Factors
History Note
English
:
2006 (1978)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22147
Unique Identifier:
D003178
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS